in an 18-month co-therapy study in manic or mixed episode patients stabilised with olanzapine plus a mood stabiliser lithium or valproate , long-term olanzapine co-therapy with lithium or valproate was not statistically significantly superior to lithium or valproate alone in delaying bipolar recurrence, defined according to syndromic diagnostic criteria.
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its affinity for lithium is approximately 15- to 18-fold greater than that for sodium 10,11 .
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manic or hypomanic symptoms certain hypomanic and manic symptoms are noticed when the quantities are large but lithium topiramate can be used for controlling them.
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